Essay Example on Biological activity Antibacterial

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Activity The antibacterial activity of the newly synthesized compounds 9a l 10a e and 11a e have been carried out with cup plate method7 by using nutrient agar medium against Gram positive bacteria Staphylococcus aureus Streptococcus pyrogenes and Gram negative bacteria Pseudomonas aeruginosa Escherichia coli Ampicillin and Chloramphenicol were employed as references for antibacterial study The activity is reported by measuring the diameter of inhibition zone in mm Gentamycin was used as standard for comparison The results are presented in Table I and Table II I N 2 chloro 4 trifluoromethyl phenyl 4 sub phenyl 1 2 3 4 tetrahydro 6 methyl 2 oxopyrimidine 5 carboxamides 9a l All the compounds 9a l tested for their antibacterial activity and all the compounds displayed good bacterial activity The compounds 9c 9d and 9k showed potent activity with Gram positive bacteria Staphylococcus aureus and where as 9a and 9b active against Streptococcus pyrogenes

The compounds 9e and 9j exhibited significant activity against Gram negative bacteria Escherichia coli and 9a 9b and 9d active against Pseudomonas aeruginosa Zone of inhibition compared with standard drugs Ampicillin and Chloramphenicol for antibacterial study However the degree of inhibition varied both with test compound as well as with the bacteria used in the present investigation These remarkable results may be due to the presence of the pyrimidine ring linked to carboxamide group Some of the compounds may be used as bacteriocides after a detailed study Results are given in Table I II 4 3 Substituted 1H pyrazol 4 yl methylidene amino 2 diphenylamino methyl 5 substituted methyl 1 2 4 triazole 3 thiones Mannich bases 10a e The compounds 10a e screened for their antibacterial activity and some of the compounds displayed good bacterial activity The compounds 10a and 10d showed potent activity with Gram positive bacteria Staphlococcus aureus and where as 10a and 10b active against Streptococcus pyrogenes The compounds 10b and 10e showed potent activity with Gram negative bacteria Escherichia coli and 10a 10b and 10d active against Pseudomonas aeruginosa Zone of inhibition compared with standard drugs Ampicillin and Chloramphenicol The notable results may be due to the presence of Nitrogen linker of pyrazole and triazole rings linked to diphenyl amine and morpholine groups The results are given in Table II III 4 3 4 Substituted 1H pyrazol 4 yl methylidene amino 2 morpholin 4 ylmethyl 5 4 methylphenoxy methyl 1 2 4 triazole 3 thiones Mannich bases 11a e The compounds 11a e screened for their antibacterial activity and few of the compounds exhibited good bacterial activity The compounds 11a and 11d displayed potent activity with Gram positive bacteria Staphlococcus aureus and where as 11b and 11d active aganist Streptococcus pyrogenes The compounds 11a and 11e showed potent activity with Gram negative bacteria Escherichia coli and 11a and 11d active aganist 



Pseudomonas aeruginosa Zone of inhibition compared with standard drugs Ampicillin and Chloramphenicol The notable results may be due to the presence of Nitrogen linker of pyrazole and triazole rings linked to diphenyl amine and morpholine groups The results are given in Table II Antifungal activity All the title compounds 9a l 10a e and 11a e were also screened for their antifungal activity against two fungal organism C albicans and A clavatus with cup plate method7 by using potato dextrose agar medium Fluconazole has been employed as standard drug for the antifungal study Diameter of zone of inhibition was measured for the plates in which the zone of inhibition in mm for each organism The results are presented in Table III and Table IV I N 2 chloro 4 trifluoromethyl phenyl 4 sub phenyl 1 2 3 4 tetrahydro 6 methyl 2 oxopyrimidine 5 carboxamides 9a l The antifungal activity results indicated that compounds 9a l are significantly toxic towards both two fungi The compounds 9c 9e 9h 9i and 9l toxic against C albicans and 9a 9b 9c 9e 9g and 9j toxic against the fungi A clavatus The antifungal activity of these compounds compared with the standard drug Fluconazole which demonstrated that they have promising activity In conclusion almost all the series of compounds 9a l are moderately toxic towards the fungi under investigation when comparison with standard Fluconazole

 This may be due to the presence of pyrimidine ring linked to carboxamide group II 4 3 Substituted 1H pyrazol 4 yl methylidene amino 2 diphenylamino methyl 5 substituted methyl 1 2 4 triazole 3 thiones Mannich bases 10a e The antifungal activity results indicated that compounds 10a e are toxic towards both two fungi The compounds 10c and 10e toxic against C albicans and 10a 10b and 10e toxic against the fungi A clavatus The antifungal activity of these compounds compared with the standard drug Fluconazole which demonstrated that they have promising activity III 4 3 4 Substituted 1H pyrazol 4 yl methylidene amino 2 morpholin 4 ylmethyl 5 4 methylphenoxy methyl 1 2 4 triazole 3 thiones Mannich bases 11a e The antifungal activity results indicated that compounds 11a e are significantly toxic towards both two fungi The compounds 11b and 11d toxic against C albicans and 11a 11b and 11e toxic against the fungi A clavatus The antifungal activity of these compounds compared with the standard drug Fluconazole which demonstrated that they have good activity Conclusion All the synthesized compounds exhibited potent activity towards both gram positive and gram negative bacteria Some of them were found to more active than standard reference drug These compounds also showed significant antifungal activity against both the fungi


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