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Investigated the thyroid C cell complexes in dogs with Antigens

B Leblancg Paulusm Andreua and M C Bonnet 199042 investigated the thyroid C cell complexes in dogs with antigens such as thyroglobulin calcitonin calcitonin gene related peptide somatostatin neuron specific enolase and neurotensin and concluded that thyroid C cell complexes are remnants of ultimobranchial from which arise thyroid follicles and C cells All C cell complexes in various proportions had stained for follicular cells C cells stellate and cuboidal cells in follicles and undifferentiated cells Albores Saavedra et al 199043 Harach44 1997 and Papotti et al45 2000 after carrying out separate studies had individually postulated that C cells could possibly derive their origin from stem endodermal cells Albores Saavedra et al 200112 was able to experimentally prove using a quail chick transplant that C cells are derived from neural crest cells and drift and relocate to Ultimobranchial bodies UBBS which in turn bring them to the thyroid gland Yoko Kameda46 2016 arrived at an understanding that thyroid C cells are endodermal in origin after conducting molecular studies on thyroid C cells of Mice 



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