I INTRODUCTION. Background and the Concept of the Blood Testis Barrier In the earlier 20th century it was reported that the blood tissue barrier concept is genuinely based on observations. When dyes were conducted to Laboratories animal they rejected to spot the Brain and testis. From this experience, the concept of blood-testis barriers BTB and blood-brain barrier BBB came into being. Another name of a blood-testis barrier is Steroli, a cell seminiferous epithelium barrier. Chiquoine Used this term for the first time after his study in which he inspects the consequences of cadmium toxicity which is associated with testicular necrosis. However, the purpose of the blood-testis barrier was not entirely valued till the late 1960s, but when it was announced by Setchell and Waites, who investigates this research that dyes were disbarred from adult rats. Actually these dyes have ability to pierce into the seminiferous tubules of prepubertal rats. They further gather fluids from various sections in the testis rete testis testicular lymph in rats sheep and seminiferous tubule vs blood plasma. And further reveals that there is sufficient contrast in their fluid composition. For instance, small hydrophilic organic compounds e.g inositol and proteins explain the existence of restricted connection b w diverse fluid sections in the testis.
An important study by Fawcett and Russell and their colleagues further explains the ultra form of blood-testis barriers in Mammalians testis.