Summary Willem de Vos Summary Introduction One of the most microbial rich niches is located in the human body The Gram negative anaerobe Akkemansia muciniphila which belongs to the Planctomycetes Verrucomicrobia Chlamydiae superphylum is found in the alimentary canal of more than 90 of the evaluated cases A muciniphila is well adapted to the human gut environment and uses glycosolated proteins of the epithelial mucus layer as its C and N source A study which is conducted earlier suggests that the health of the gastrointestinal tract is correlated with the abundance of A muciniphila For example when the density of A muciniphila is low this is associated to diabetes type 1 Crohn's disease CD and in Ulcerative colitis UC Furthermore the recovery of the mucus layer in the human colon and decreasing endotoxemia are associated with A muciniphila State of the art There is not much known about the interactions between A muciniphila and the host nor how it handles the different environmental circumstances Previous studies do suggest that there is a positive consequence for the health of the gastrointestinal tract when
