Student's T Test compares the significant difference between two groups two means In this study paired t test is used to compare groups and test the significant difference between two sets of data If the data are significant given by the P 0 05 were considered as significant data P 0 01 P 0 001 P 0 0001 The multiple t test compares the statistical significance probabilities analysis for several t tests at once The two way ANOVA used to compare independent variables of interest and to understand if there is an interaction between them in different conditions Our hypothesis findings needed more common hypothesis tests such as two way analysis of variance ANOVA In this study we mainly have two independent factors that are autophagy and IR with different time points This basic research begins with a question that whether autophagy inhibition is more effective for the PCa patients treatment combined with radiotherapy RT rather than RT treatment alone To test this question we need to transform basic question to a testable hypothesis labeled H0 named as a Null hypothesis which takes the following form H0 Whether autophagy inhibition is NOT more effective for the PCa patients treatment combined with RT rather than RT treatment alone
Evaluation of tablets Pre compression parameters Angle of repose Angle of repose was determined by funnel method Accurately weighed 10 g granules were taken in the funnel Height of the funnel was adjusted such that the tip of the funnel just touches the apex of the heap of powder The powder was allowed to flow through funnel freely onto the surface The diameter of the powder cone was measured and angle of repose was calculated using the following equation 12 tan Ɵ h r where Ɵ angle of repose h height of cone r radius of cone base Bulk density Take about 100 gm of lansoprazole microparticles into a dry 250 ml cylinder and note the unsettled apparent volume Vo Bulk density was calculated in g ml 13 By using the formula Bulk density M Vo Where M weight of the sample taken Vo bulk volume of the drug Tapped density Take about 100 gm of lansoprazole microparticles into a dry 250 ml cylinder and tap the cylinder upto 500 times and note the tapped volume Va 12 Then the tapped density was calculated using the following formula Tapped density M Va Where M weight of the sample taken Va final tapped volume of drug Carr s index The compressibility index of granules was determined using carr s index Carr s index Tapped density Bulk density Tapped density X 100 Hausner s ratio The Hausner s ratio was determined by formula Hausner s ratio Tapped density Bulk density Evaluation of Post compression parameters of lansoprazole microsphere compressed tablets 1 Tablets thickness 13 Tablets thickness was measured by using Vernier calliper Five tablets was taken and placed between the two arms of the Vernier calliper 2 Tablet hardness 14
