Essay Examples on New York Graduate School of Psychoanalysis

The efficacy of Omapatrilat and Sacubitril in the treatment of heart failure

Compare and contrast the efficacy of Omapatrilat and Sacubitril in the treatment of heart failure Heart failure occurs when there is a decrease in cardiac output Due to this the body releases more noradrenaline and adrenaline as a response to compact this change Thereby the heart beats more rapidly and gets bigger These changes can cause and lead to other complications associated with heart failure such as hypertension arrhythmias aneurysms and so forth Stages of heart failure is popularity identified using the New York Association Heart Failure Scale which defines the symptoms of heart failure in classes as shown in the table below Looking at the renin angiotensin aldosterone system RAAS is used as an indicator of conceding heart failure The RAAS helps in regulation of cardiac function and blood pressure Angiotensinogen is broken down by the enzyme renin to produce angiotensin I The release of renin is due to a response to decrease in blood pressure Angiotensin I is converted into angiotensin II by an angiotensin converting enzyme ACE Angiotensin II is a known to be a potent vasoconstrictor 2 High levels of angiotensin II leads to increased levels of aldosterone and a higher affinity for water retention and uptake of sodium This also affects the sympathetic nervous system In heart failure when blood pressure decreases there is an increase in the volume of blood produced 



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