Writing Resources
Experimental Section Efficient synthesis of some novel 1 2 3 4 tetrahydropyrimidine 5 carboxamide derivatives in solvent free conditions under microwave irradiation N 2 Chloro 4 trifluoromethyl phenyl 4 2 methoxyphenyl 6 methyl 2 oxo 1 2 3 4 tetrahydropyrimidin 5 carboxamide 53a Conventional method To a solution of N 2 chloro 4 trifluoromethyl phenyl 3 oxobutanamide 50 0 01 mol in ethanol 30ml was sequentially added Benzaldehyde 51a 0 01 mol urea 52 0 015 mol followed by catalytic amount of p Toluenesulfonic acid and refluxed at 70 75 C for 8 5 hr After completion of the reaction monitored by TLC the reaction mixture was treated with ice cold water The resulting solid product was filtered washed with water and purified by recrystallization from ethanol to afford 53a Microwave method To a mixture of N 2 chloro 4 trifluoromethyl phenyl 3 oxobutanamide 50 0 01 mol Benzaldehyde 51a 0 01 mol urea 52 0 015 mol and a catalytic amount of p Toluenesulfonic acid was added DMF 10drops Reaction mixture was subjected to microwave irradiation for 7 0 min at 400 W On completion of reaction monitored by TLC the contents were poured into crushed ice The solid thus obtained was separated by filtration and purified by recrystallization from ethanol to produce 53a IR KBr cm 1 3410 3240 For NH 3071 For C H of Phenyl ring 2936
