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Introduction Cancer arise due to the sequential variation of genes that control cell growth Leon and his colleagues suggested that the ct DNA circulating tumor DNA have found in increased concentration in cancer patients as compared to those patients who are non malignant They have found that the normal patients have DNA concentration 13ng ml while cancer patients have 180 ng ml This increasing amount of ct DNA is due to the lack of proper treatment Experiment with many kinds of malignancies like leukaemia lung gastrointestinal and breast cancer they have found that the ct DNA bearing massive quantity of tumor cells when this DNA was extracted and purified it is also determine that cancer cells have biophysical properties like decrease strand stability Due to this property expose to various carcinogens separation of DNA strand can be determine by increase in hyperchromicity so cancer cell DNA expose at low temperature Moreover stimulation of DNA synthesis in vitro indicated that the increase in samples of DNA from cancer patients having 64 to 300 and no increase have seen in healthy donors they indicated that the DNA from the plasma of cancer patients showing a hyperchromic effects at room temperature after adding carcinogens other control DNA showing hyperchromic effects after the addition of KOH
