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Parkinson's disease PD is a motor disorder characterised by the degeneration of the dopaminergic neurons in the nigrostriatal pathway of the basal ganglia 1 It is the second most common neurodegenerative disease after Alzheimer's Disease Studies from the western populations have shown significant differences in the various features of the disease between the males and the females with regard to age of onset progression and severity of the motor symptoms 2 3 4 These are attributed to presumptive hormonal interactions between estrogens and dopamine 2 5 While numerous studies are available to support these findings from the western world only a handful of such studies have been conducted from Northern India so as to test the validity of the hypothesis in our population 6 7 However with increased recognition of the Non motor symptoms NMS in PD it is becoming progressively more important to evaluate and study the gender differences among NMS 8 Studies from the Western population have shown increased prevalence of behavioural disorders and rigidity in men and increased dyskinesias and depression in women 5
