Alcoholic Fatty Liver The liver is a highly metabolic organ Viollet et al 2009 It acts as a pivot point between the fasting and feeding states and as such has both catabolic and anabolic capabilities These processes are implicated when an excess of alcohol results in inadequate metabolism endoplasmic reticulum stress and increased fatty acid and triglyceride synthesis all of which lead to steatosis The peroxisome proliferator activated receptor α is critical for alcohol metabolism and when down regulated or depleted results in massive fat accumulation Zeng et al 2012 Bala et al 2016 Sterol regulatory element binding proteins SREBP and 50 adenosine monophosphate activated protein kinase AMPK are also implicated in ALD since they play an important role in regulating lipid metabolism and their expression is altered under alcohol consumption Altamirano and Bataller 2011 Zhang et al 2015 Down regulation of AMPK by alcohol decreases its ability to inactivate SREBP and increases adenylyl cyclase activity contributing to steatosis Garcia et al 2008
We live in a world which is constantly facing the threat of extinction due to Global warming Finding sustainable energy with minimal carbon emission is one of the most vital challenges of present times My decision to pursue Postgraduate study is inspired by the desire to combine my creativity with specialized knowledge to explore and enhance sustainable energy for this ever changing world I have chosen Master s in Nuclear Energy as the field of my Masters studies wherein I am determined to obtain a leadership position in the industrial research and innovation I strongly believe that higher education can be the staircase of success if anyone tries to pick the right area that matches with his interest To illustrate my intentions about pursuing chosen Master s in Nuclear Energy I would like to shed some light on my educational background and energy crisis in my country From my secondary education level I had keen interest to spend a lot of time to figure out the logical explanation of mathematical problems I participated in many science fairs organized by different institution to engage myself in competitions like math Olympiad project showcasing etc