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Malakoplakia of Gall Bladder Case report and review Introduction

Malakoplakia of Gall Bladder Case report and review Introduction Malakoplakia MP is a rare granulomatous disorder mostly involving urinary tract Few cases are reported about malakoplakia in gallbladder GB It morphologically mimics other lesions like xanthogranulomatous cholecystitis as well as malignancy 1 We report a case of gall bladder wall thickness clinically suspected to be carcinoma and then revealed as malakoplakia We will discuss the condition in the context of other causes of gallbladder wall thickness Case Report A 65 year old nondiabetic female patient presented with a complaint of upper abdominal discomfort Abdominal examination showed palpable non tender mass in the right hypochondrium Signs and symptoms of acute pancreatitis were negative Hemogram liver function tests renal function tests Serum amylase and serum lipase were within normal levels Ultrasonography whole abdomen revealed multiple stones contracted gall bladder with wall thickening and excluded presence of pancreatic and peripancreatic tissue edema Clinically Gall bladder carcinoma was suspected Open cholecystectomy was performed and gall bladder specimen was referred to histopathological examination HPE Grossly GB specimen was measured 10x6x4 cm with thickened wall Dissection showed greenish velvety mucosa with areas of ulceration obliteration of the cavity by diffuse nodules with yellowish discoloration and impacted three blackish stones Figure 1 HPE was done after staining the paraffin blocks with hematoxylin and eosin Sections examined from gall bladder wall revealed subtotally denuded mucosal lining with thickening of the wall 

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