Essay Examples on Guilford College

The Walt Disney Company DIS

The Walt Disney Company DIS commonly known as Disney is the best loved media and entertainment company in the world headquarter is located at the Walt Disney Studios in Burbank California This company is the world's second largest media conglomerate in terms of revenue after Comcast It was founded on October 16 1923 by brothers Walt Disney and Roy O Disney By diversifying into live action film production and television from the animation industry Disney has created corporate division and operated a vast international entertainment empire in four business sections including Disney Media Networks Walt Disney Theme Parks and Resorts Walt Disney Studio Entertainment and Disney Consumer Products Interactive Media 1 0 1 Company Units Media network is a primary unit of The Walt Disney Company that includes various cable channels and broadcast TV networks television production and distribution operations and also owned the operated television stations and radio stations The Company's Walt Disney Imagineering unit for Parks and Resorts designs and develops new theme park concepts and features especially the resort properties The Studio Entertainment segment produces and acquires live action and animation pictures direct to video content music and songs and live stage plays 

1 pages | 382 words

Previous report has indicated that CRMP2 is a key Player

Previous report has indicated that CRMP2 is a key player in determining the localisation and trafficking posttranslational modification of CRMP2 can affect trafficking of Nav1 7 both positively or negatively Studies suggest that CRMP2 can interact with Nav1 7 causing SUMOlaytion to occurs which allows it to be phosphorylated by Cdk5 and this has proven to be obligatory for promoting positive regulation in the transport of channel to the plasma membrane When CRMP2 is detached from SUMO it can recruit scaffold protein Numb and be phosphorylated by Fyn and allow Nedd4 2 to bind hence allow internalisation of NaV1 7 Although CRMP2 can regulate Nav1 7 expression both ways the phosphorylation by Cdk5 was shown to be dominant over the phosphorylation by Fyn REF It is also noted that CRMP2 has a higher selectivity to Nav1 7 than other VGSC REF The reason for CRMP2 having a higher affinity to Nav1 7 is not fully understood one hypothesis is that CRMP2 have a higher affinity to the Nav1 7 intracellular domain that are not conserved in other isoforms

1 pages | 339 words