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Due to increasing rates of incidents often late diagnosis and restricted options for treatment Hepatocellular carcinoma HCC is a major concern for public health It is known that Transforming growth factor beta TGF β provides cytostatic signals in both the primary phases of liver damage and in regeneration However TGF β also deploys tumour promoting effects throughout the progression of liver cancer and during onset In this study changes in mRNA levels of E cadherin and Vimentin were measured using quantitative reverse transcriptase PCR qRT PCR to assess the impact of TGF β on human hepatocellular carcinoma cells Results showed significant variation in E cadherin and vimentin expression One sample treated with TGF β stimulated downregulation of E cadherin whereas the other sample that was treated stimulated up regulation of vimentin Introduction The third most significant cause of cancer related mortality worldwide is Hepatocellular carcinoma HCC Parkin et al 2005 The prognosis for many HCC patients remains bleak despite scientific advances This is due to intrahepatic and extrahepatic metastasis and recurrence of cancer post surgery Contributing to the lack of reliable therapy for advanced
