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Introduction Phthalic acid is a colorless aromatic dicarboxylic acid with an isomer of iso phthalic acid and Terephthalic acid The most commonly used commercial form of phthalic acid is phthalic anhydride Phthalic acid used as an initiator for the formation of phthalates Plastic goods are made from phthalates to increase their softness and flexibility Phthalates formed by the esterification of phthalic acid at 2 carboxyl functional groups Plasticizers used in several products such as for the formation of toys cosmetics medical tubes blood bags plastic bags and plastic bottles Diethylhexyl phthalate DEHP and polyvinyl chloride used for the hemodialysis of the patients According to the research it was found that in the U S over 97 Americans were found to have phthalate metabolites such as monoethyl phthalate MEP mono butyl phthalate MBP and mono benzyl phthalate MBzP in their urine Phthalates have a negative impact on human health as they play an important role in causing asthma cardiotoxicity hepatotoxicity genital diseases and nephrotoxicity 1 High molecular weight phthalates such as butyl benzyl phthalate di 2 ethylhexyl phthalate and a mixture of di n octyl phthalate renowned for their use as plasticizer in polyvinyl chloride materials such as food packaging flooring and medical devices Phthalates that are added to cosmetics and personal care products as a solvent fixatives and adhesives are low molecular weight phthalates such as dimethyl phthalate and diethyl phthalate Phthalates cause environmental pollution due to their non covalent bonds with parent materials 2
