Essay Examples on University of Chicago

Gabather AB is a Swedish Biotech Company

INTRODUCTION Gabather AB is a Swedish Biotech Company dedicated for development of novel drug candidates for the treatment of Central nervous system CNS disorders It focuses on four different areas including anti depressants anti psychotics anxiolytics and analgesics It mainly focuses on the potential candidates that interact with Gamma amino butyric acid GABA It has developed a highly potent novel lead compound GT 002 by focusing on the area of antipsychotics that is known to target and bind with GABAA receptor and cause a behavioural effect 12 1 1 GABA Gamma Aminobutyric Acid GABA is an amino acid of the central nervous system CNS The chemical formula of GABA is C4H9NO2 1 It is the most potent depressive neuro amine in mammalian brain tissues It is synthesised from glutamate a human brain cortex excitatory neurotransmitter by glutamate decarboxylase enzyme 2 4 Whereas GABA is the main inhibitory neurotransmitter in human brain and activates many receptor subtypes in mammalian central nervous system It mainly targets the ionotropic transmembrane GABAA receptor thereby inhibiting the neurotransmission 

The effect of GABA is modulated by the modulators of GABAA receptor by binding to the allosteric sites which are the common drug targets 3 The Chemical formula of Gamma amino butyric acid GABA The GABA is one of the key neurotransmitters involved in the anxiolytic action of many drugs used to treat anxiety disorders by counterbalancing the action of glutamate excitatory neurotransmitter Novel GABAergic agents such as tiagabine modulate the overall effect of GABA system and thereby used in the treatment of anxiety disorders 5 Anxiety disorders are usually due to mixture of feelings such as worry and fear

2 pages | 531 words