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Coronary artery disease CAD is a Complex Trait

Coronary artery disease CAD is a complex trait caused by a number of genetic and environmental factors CAD remains a leading cause of death in most developing countries According to estimates by the World Health Organization WHO nearly seven million people worldwide die of CAD each year equally among men and women with most of these deaths occurring in both high and low income countries 1 The prevalence of CAD worldwide is rapidly rising Over the past twenty years CAD has become the leading cause of death in Kingdom of Saudi Arabia KSA and has reached epidemic proportions Mortality rates associated with CAD have shown an exceptional increase particularly in fast developing economies like the KSA The maximum increase of coincided with fast economic growth and urbanization that promotes sedentary lifestyle high energy fat food smoking low intake of fruits and vegetables and mainly developing of oxidative stress These factors have undoubtedly contributed to the epidemic of CAD in KSA 2 More than 80 of sudden cardiac deaths are caused by atherosclerotic CAD Atherosclerosis is characterized by the buildup of fatty lesions inflammation and scarring of arterial walls with oxidative stress as a primary contributing factor Atherosclerosis is an inflammatory disease

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