Essay Example on Tumor necrosis factor TNF is a cell signaling protein Cytokin








Tumor necrosis factor TNF is a cell signaling protein cytokine involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction The primary role of TNF is in the regulation of immune cells TNF being an endogenous pyrogen is able to induce fever apoptotic cell death cachexia inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 IL6 producing cells Tumor necrosis factor can also be made in the laboratory It may boost a person's immune response and also may cause necrosis cell death of some types of tumor cells Tumor necrosis factor is being studied in the treatment of some types of cancer It is a type of cytokine Also called TNF The Start Codon of this protein is 176 ATG and the Stop Codon of the protein is 875 TGA Tumor Necrosis Factor is 233 amino acids long L Tumor Necrosis Factor protein 7 MSTE drawing Tumor Necrosis Factor is associated with the disease Bacterial Toxic shock

This disease occurs within a few hours after infection by certain gram negative bacteria including E coli P aeruginosa and N meningitides The symptoms associated with this disease are decrease in blood pressure fever diarrhea and blood clotting in various organs These are all results of an overproduction of TNF Monoclonal antibodies to TNF may provide an effective treatment to this disease by binding the free TNF Toxic Shock syndrome is a rare but serious medical condition caused by a bacterial infection It is caused when the bacterium Staphylococcus aureus gets into the bloodstream and produces toxins Even though Toxic Shock syndrome is linked to superabsorbent tampon use in menstruating women this condition can also affect men children and people of all ages Some symptoms of Toxic Shock syndrome can vary from person to person In most cases symptoms appear suddenly Common signs of this condition include Sudden fever low blood pressure headache muscle aches confusion diarrhea nausea vomiting rash redness of eyes mouth and throat and seizures Usually when infection occurs it is because bacteria enters your body through an opening in your skin such as a cut sore or other wound Experts are not sure why tampon use sometimes leads to Bacterial Toxic Shock syndrome Some people believe that a tampon left in place for a long period of time attracts bacteria Another possibility is that tampon fibers scratch the vagina creating an opening for bacteria to enter your bloodstream 

Toxic shock syndrome is a medical emergency Some people with the condition have to stay in the intensive care unit for several days so that medical staff can closely monitor them Your doctor will most likely recommend an intravenous IV antibiotic to help you fight the bacterial infection in your body This will require the placement of a special IV line called a peripherally inserted intravenous catheter or PICC line You will receive 6 8 weeks of antibiotics at home If this is the case an infectious disease doctor will closely monitor you Sometimes depending on the underlying cause other treatment methods for Toxic Shock syndrome are necessary For example a doctor may need to remove a foreign object from your body if it has triggered a Toxic Shock These foreign objects can include a vaginal sponge or tampon If an open wound or surgical wound caused your toxic shock syndrome the doctor will drain pus or blood form the wound to help clear up an infection Other possible treatments that may be necessary include medication to stabilize blood pressure IV fluids to fight Dehydration and gamma globulin injections to suppress inflammation and boost your body s immune system The following is current research from http europepmc org abstract med 7339069 on TNF Tumor Necrosis factor TNF is an active element of serum taken from Corynebacterium parvum C parvum infected mice dealt with with lipopolysaccharide LPS To discover the production site of TNF we tried to block TNF manufacturing by the use of the following reagents carrageenan hydrocortisone and trypan blue Following the injection of a massive dose of carrageenan administered before C parvum treatment TNF production became completely blocked

However when administered after C parvum treatment but prior to LPS injection no blockage became found Injecting hydrocortisone before the LPS injection also blocked TNF launch this treatment while administered before the injection of C parvum had no observable impact on TNF manufacturing A large dose of trypan blue administered before the LPS injection additionally blocked the discharge of TNF A low dose of trypan blue ended in only partial blockage of TNF production A large dose of trypan blue administered prior to C parvum treatment also showed partial blockage of TNF production Macrophage enriched peritoneal exudate cells p c taken from mice infected with C parvum launched TNF into the supernatant after stimulation with LPS these effects strongly propose that the production site of TNF is located inside the activated macrophage and deeply associated with lysosome

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