Essay Example on Tumor necrosis factor TNF is a cell signaling protein Cytokin

This disease occurs within a few hours after infection by certain gram negative bacteria including E coli P aeruginosa and N meningitides The symptoms associated with this disease are decrease in blood pressure fever diarrhea and blood clotting in various organs These are all results of an overproduction of TNF Monoclonal antibodies to TNF may provide an effective treatment to this disease by binding the free TNF Toxic Shock syndrome is a rare but serious medical condition caused by a bacterial infection It is caused when the bacterium Staphylococcus aureus gets into the bloodstream and produces toxins Even though Toxic Shock syndrome is linked to superabsorbent tampon use in menstruating women this condition can also affect men children and people of all ages Some symptoms of Toxic Shock syndrome can vary from person to person In most cases symptoms appear suddenly Common signs of this condition include Sudden fever low blood pressure headache muscle aches confusion diarrhea nausea vomiting rash redness of eyes mouth and throat and seizures Usually when infection occurs it is because bacteria enters your body through an opening in your skin such as a cut sore or other wound Experts are not sure why tampon use sometimes leads to Bacterial Toxic Shock syndrome Some people believe that a tampon left in place for a long period of time attracts bacteria Another possibility is that tampon fibers scratch the vagina creating an opening for bacteria to enter your bloodstream 

However when administered after C parvum treatment but prior to LPS injection no blockage became found Injecting hydrocortisone before the LPS injection also blocked TNF launch this treatment while administered before the injection of C parvum had no observable impact on TNF manufacturing A large dose of trypan blue administered before the LPS injection additionally blocked the discharge of TNF A low dose of trypan blue ended in only partial blockage of TNF production A large dose of trypan blue administered prior to C parvum treatment also showed partial blockage of TNF production Macrophage enriched peritoneal exudate cells p c taken from mice infected with C parvum launched TNF into the supernatant after stimulation with LPS these effects strongly propose that the production site of TNF is located inside the activated macrophage and deeply associated with lysosome