Essay Example on LSchiff base condensation products of primary amines with carbonyl Compounds

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Schiff base condensation products of primary amines with carbonyl compounds also known as anils imines or azomethines contain a lone pair of electrons on the sp2 hybridized nitrogen atom of the imine moiety Due to their facile preparation synthetic flexibility and the biocidal properties of the imine group Schiff bases are considered as privileged ligands Cytotoxicity activity of Ru II Cl2PMDPcomplex was carried out against MCF 7 cell line at different concentrations to determine the IC50 50 growth inhibition by MTT assay Results of different concentrations of Ru II Cl2PMDPcomplex including 6 25 12 5 25 50 and 100 µg ml are tabulated in Table MCF 7 cells incubated with Ru II Cl2PMDPcomplex at 6 25 12 5 and 25 µg ml the amount of formazan was similar to control cells while in other cells it was distinctly lower the quantity of formazan produced varied between different concentration of Ru II Cl2PMDPcomplex treated cells as shown in Fig The formation of formazan crystals decreases when the concentration of Ru II Cl2PMDPcomplex increases in MCF 7 cells MTT assay of Ru II Cl2PMDPcomplex showed significant effect on MCF 7 cell line in a concentration range between 50 µg ml to 100 µg ml compared with control This Ru II Cl2PMDPcomplex exerts high cytotoxicity in 100 µg ml concentration against MCF 7 cell line with 23 86 percent of cell growth inhibition The IC50 values of Ru II Cl2PMDPcomplex on MCF 7 was 30 17 µg ml In addition the cytotoxicity activity of Ru II Cl2PMDPcomplex was carried out against HT 29 cell line at different concentrations to determine the IC50 50 growth inhibition by MTT assay 



Results of different concentrations of compound 2 including 6 25 12 5 25 50 and 100 µg ml are tabulated in Table In cells incubated with Ru II Cl2PMDPcomplex at 6 25 µg ml the amount of formazan was similar to control cells while in other cells it was distinctly lower the quantity of formazan produced varied between different concentration of Ru II Cl2PMDPcomplex treated cells as shown in Fig The formation of formazan crystals decreases when the concentration of compound 2 increases in HT 29 cells The inhibitory concentration of Ru II Cl2PMDPcomplex against HT 29 cell line was observed at 100 µg ml compared with control This Ru II Cl2PMDPcomplex showed 51 2 percent of cell growth inhibition compare to control in HT 29 cells The IC50 values of Ru II Cl2PMDPcomplex on HT 29 cell line was found to be 28 29 µg ml Cytotoxicity activity of Ru II bpy PMDP complex was carried out against MCF 7 cell line at different concentrations to determine the IC50 50 growth inhibition by MTT assay Results of different concentrations of Ru II bpy PMDP complex including 6 25 12 5 25 50 and 100 µg ml are tabulated in Table In MCF 7 cells incubated with Ru II bpy PMDP complex at 6 25 µg ml the amount of formazan was similar to control cells while in other cells it was distinctly lower the quantity of formazan produced varied between different concentration of Ru II bpy PMDP complex treated cells as shown in Fig 



The formation of formazan crystals decreases when the concentration of Ru II bpy PMDP complex increases in MCF 7 cells MTT assay of Ru II bpy PMDP complex showed significant effect on MCF 7 cell line in a concentration range between 50 µg ml to 100 µg ml compared with control This Ru II bpy PMDP complex exerts high cytotoxicity in 100 µg ml concentration against MCF 7 cell line with 57 27 percent of cell growth inhibition The IC50 values of Ru II bpy PMDP complex on MCF 7 was 21 57 µg ml Numerous Ru II and Ru III complexes were tested in vitro against HeLa MCF 7 A549 and SW620 cell lines however among the hundreds of complexes only a very limited number showed low IC50 values HeLa is the most tested cancer cell line Cytotoxicity of ruthenium complexes against this cancer cell line varies from negligible Currently Ru drugs are considered the most promising alternatives to platinum drugs active by interaction with DNA ruthenium complexes also operate via different mechanisms From the present study it was found that the percentage of cancer cells growth inhibition was increasing with increasing concentration of test compounds 



The results of cytotoxic data indicated that most of the synthesized compounds showed moderate to high cytotoxic potential in both MCF 7 and HT 29 cell lines Therefore the ruthenium centered complexes are being researched for possible anticancer properties Ruthenium is a versatile catalyst In particular ruthenium coordination compounds have shown promising application as anticancer agents and may lead to the development of improved ruthenium chemotherapeutic drugs Overall the high potential and versatility of the Ru complexes attest to the importance they assume in chemistry and other scientific and technical areas and undoubtedly ensure the emergence in the near future of further developments serving mankind

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